No. Depo Provera prevents pregnancy by stopping the release of the egg from the ovaries. If the egg is not released, then it cannot be fertilized by the sperm. In addition to preventing the egg from being release from the ovaries, Depo makes the uterine lining very thin or prevents it from thickening at all. Every month the body prepares for pregnancy by thickening the uterine lining in order to protect the embryo (the fertilized egg). If an egg is not fertilized by a sperm, the lining is not needed, and it comes out as a period. More than half of the women on Depo will stop having a period altogether around the 2nd or 3rd injection. This is normal.
However, once you stop Depo, it can prevent pregnancy from six months up to a year afterwards. No matter how long you were on Depo it does not permanently prevent you from having children. Of course every woman’s body is different. If you don’t want to get pregnant, but want to stop Depo, another form of birth control should be started three months after your last Depo injection. You should go see your health care provider for a discussion on all birth control option available to you and choose the one that’s best for you.